Publications

Mitigation of chronic glucotoxicity-mediated skeletal muscle atrophy by arachidonic acid

The research paper explores the molecular mechanisms of arachidonic acid (AA) supplementation in reversing the effects of chronic hyperglycemia-induced toxicity on skeletal muscle myogenesis in C2C12 cells. Chronic hyperglycemia activates atrophy-related pathways in skeletal muscles, leading to inflammation and muscle degeneration. The study investigates how AA supplementation mitigates inflammation, reduces reactive oxygen species (ROS) production, and enhances protein synthesis in hyperglycemic conditions. Results show that AA supplementation counteracts the pro-inflammatory cytokines and ROS production induced by high glucose levels, restoring protein synthesis that was suppressed under glucotoxic conditions. The cytoprotective actions of AA against hyperglycemia-induced cytotoxicity are highlighted.

Life Sciences

The elusive role of myostatin signaling for muscle regeneration and maintenance of muscle and bone homeostasis

The research paper discusses the crucial role of myostatin in skeletal muscle regeneration and its implications for conditions such as sarcopenia, muscular dystrophies, and cachexia. The paper highlights how skeletal muscles play a vital role in the musculoskeletal system and how their proper functioning is essential for stability and mobility. Improper functioning of skeletal muscles can lead to diseases like sarcopenia, muscular dystrophies, and cachexia. The paper focuses on the interplay of signaling pathways involved in skeletal muscle regeneration, hypertrophy, atrophy, and degeneration, with myostatin being a significant regulator. It discusses the impact of myostatin on muscle mass regulation, highlighting its involvement in conditions like cachexia and inflammatory processes in rheumatoid arthritis. Clinical trials of various myostatin inhibitors and activators are reviewed, showing varying degrees of efficacy and safety profiles. The potential of targeting myostatin for therapeutic interventions in muscle-wasting disorders and inflammatory bone diseases is emphasized, offering hope for improved treatment strategies in the future.

Osteoporosis and Sarcopenia

Unlocking the Potential of Obestatin: A Novel Peptide Intervention for Skeletal Muscle Regeneration and Prevention of Atrophy

The research paper explores the potential of obestatin, a peptide derived from the same gene as ghrelin, in preventing skeletal muscle wasting and inducing myogenesis. Obestatin functions through the GPR39 receptor, similar to ghrelin, and targets proteins like FoxO family members to combat skeletal muscle atrophy. It induces the transcription of Pax7, crucial for muscle stem cell mobilization. The paper discusses the anti-atrophic effects of obestatin compared to ghrelin, highlighting their synergistic and complementary activities. Mechanistic studies reveal the role of obestatin in inhibiting FoxO4 and the autophagy pathway, crucial for muscle wasting. Furthermore, obestatin influences intracellular signaling pathways involving CaMK II and ERK1/2 for muscle regeneration. The paper suggests a potential therapeutic role for obestatin in preventing skeletal muscle atrophy and sarcopenia, emphasizing the need for further research on obestatin's clinical applications in combination therapies.

Molecular Biotechnology